 This anaesthetic has more than one structural configuration. An example low energy conformer is shown. Surface View:
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Surface view shows the electrostatic potential of the conformer mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
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| In Vivo Activity Data | ||
| Immobility: MAC Rat [Pa/PI Corrected] (atm) | 0.053 ± 0.004 (n=4) | Fang Z, Sonner J, Laster MJ, et al. Anesth Analg 1996;83:1097-104 |
|---|---|---|
| Immobility: MAC Rat (atm) | 0.0586 ± 0.0043 (n=4) | Fang Z, Sonner J, Laster MJ, et al. Anesth Analg 1996;83:1097-104 |
| Physical Properties | ||
| Saline / Gas Partition Coeff. at 37°C | 0.088 ± 0.002 | Fang Z, Sonner J, Laster MJ, et al. Anesth Analg 1996;83:1097-104 |
| Olive Oil / Gas Partition Coeff. at 37°C | 139 ± 4 | Fang Z, Sonner J, Laster MJ, et al. Anesth Analg 1996;83:1097-104 |
| Octanol / Gas Partition Coeff. at 37°C | 145 ± 2 | Fang Z, Sonner J, Laster MJ, et al. Anesth Analg 1996;83:1097-104 |
| Blood / Gas Partition Coeff. at 37°C | 1.74 ± 0.05 (n=4) | Fang Z, Sonner J, Laster MJ, et al. Anesth Analg 1996;83:1097-104 |
| Arterial / Inspired Partial Pressure (Pa/PI) | 0.901 ± 0.021 (n=4) | Fang Z, Sonner J, Laster MJ, et al. Anesth Analg 1996;83:1097-104 |
| Calculated Molecular Properties | ||
| van der Waals Volume | 86 Å3 | |
| van der Waals Surface Area | 128 Å2 | |
| Solvent Accessible Volume | 332 Å3 | (based on a 1.4Å probe) |
| Solvent Accessible Surface Area | 251 Å2 | (based on a 1.4Å probe) |
| Notes | ||
| Twitching at 0.0026 atm | ||
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
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Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014