![]() This anaesthetic has more than one structural configuration. An example low energy conformer is shown. Surface View:
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Surface view shows the electrostatic potential of the conformer mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
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In Vivo Activity Data | ||
Immobility: MAC Rat [Pa/PI Corrected] (atm) | 0.00577 (n=6) | Eger EI II and Laster MJ. Anesth Analg 2001;92:1477-82 |
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Immobility: MAC Rat (atm) | 0.0146 ± 0.0014 (n=6) | Eger EI II and Laster MJ. Anesth Analg 2001;92:1477-82 |
Physical Properties | ||
Saline / Gas Partition Coeff. at 37°C | 0.96 ± 0.02 | Eger EI II and Laster MJ. Anesth Analg 2001;92:1477-82 |
Olive Oil / Gas Partition Coeff. at 37°C | 305 ± 4 | Eger EI II and Laster MJ. Anesth Analg 2001;92:1477-82 |
Blood / Gas Partition Coeff. at 37°C | 9.02 ± 0.41 | Eger EI II and Laster MJ. Anesth Analg 2001;92:1477-82 |
Calculated Molecular Properties | ||
van der Waals Volume | 98 Å3 | |
van der Waals Surface Area | 146 Å2 | |
Solvent Accessible Volume | 404 Å3 | (based on a 1.4Å probe) |
Solvent Accessible Surface Area | 301 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
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Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014