 This anaesthetic has a single low-energy conformer. Surface View:
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Surface view shows the electrostatic potential of the structure mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
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| In Vivo Activity Data | ||
| Immobility: MAC Rat (atm) | 66.5 ± 13.4 (n=30) | Eger EI II, Liu J, Koblin DD, et al. Anesth Analg 1994;79:245-51 |
|---|---|---|
| Immobility: MAC Dog (atm) | 26 ± 8 (n=6) | Eger EI II, Lundgren C, Miller SL & Stevens WC. Anesthesiology 1969;30:129-35 |
| Physical Properties | ||
| Saline / Gas Partition Coeff. at 37°C | 0.0041 ± 0.0001 (n=4) | Eger EI II, Liu J, Koblin DD, et al. Anesth Analg 1994;79:245-51 |
| Olive Oil / Gas Partition Coeff. at 37°C | 0.052 ± 0.002 (n=4) | Eger EI II, Liu J, Koblin DD, et al. Anesth Analg 1994;79:245-51 |
| Octanol / Gas Partition Coeff. at 37°C | 0.26 | |
| Blood / Gas Partition Coeff. at 37°C | 0.079 ± 0.002 | |
| Calculated Molecular Properties | ||
| van der Waals Volume | 48 Å3 | |
| van der Waals Surface Area | 76 Å2 | |
| Solvent Accessible Volume | 229 Å3 | (based on a 1.4Å probe) |
| Solvent Accessible Surface Area | 189 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
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Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014