 This anaesthetic has more than one structural configuration. An example low energy conformer is shown. Surface View:
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Surface view shows the electrostatic potential of the conformer mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
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| In Vivo Activity Data | ||
| Immobility: MAC Rat [Pa/PI Corrected] (atm) | 0.0024 (n=10) | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1994;79:1049-55 |
|---|---|---|
| Immobility: MAC Rat (atm) | 0.0142 ± 0.0023 (n=10) | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1994;79:1049-55 |
| Physical Properties | ||
| Saline / Gas Partition Coeff. at 37°C | 0.0041 ± 0.0002 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
| Olive Oil / Gas Partition Coeff. at 37°C | 14400 ± 1220 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
| Octanol / Gas Partition Coeff. at 37°C | 23100 ± 3920 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
| Blood / Gas Partition Coeff. at 37°C | 17.3 ± 1.79 | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1994;79:1049-55 |
| Arterial / Inspired Partial Pressure (Pa/PI) | 0.17 ± 0.02 | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1994;79:1049-55 |
| Vapour Pressure at 20°C (atm) | 0.00276 | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1993;77:12-8 |
| Calculated Molecular Properties | ||
| van der Waals Volume | 180 Å3 | |
| van der Waals Surface Area | 280 Å2 | |
| Solvent Accessible Volume | 646 Å3 | (based on a 1.4Å probe) |
| Solvent Accessible Surface Area | 443 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
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Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014