![]() This anaesthetic has more than one structural configuration. An example low energy conformer is shown. Surface View:
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Surface view shows the electrostatic potential of the conformer mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
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In Vivo Activity Data | ||
Immobility: MAC Rat [Pa/PI Corrected] (atm) | 0.0088 ± 0.0015 (n=4) | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1994;79:1049-55 |
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Immobility: MAC Rat (atm) | 0.017 ± 0.0025 (n=4) | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1994;79:1049-55 |
Convulsant: Rat ED50 (atm) | 0.015 ± 0.0017 (n=4) | Eger EI II, Koblin DD, Sonner J, et al. Anesth Analg 1999;88:884-92 |
Physical Properties | ||
Saline / Gas Partition Coeff. at 37°C | 0.0059 ± 0.0002 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
Olive Oil / Gas Partition Coeff. at 37°C | 1430 ± 18 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
Octanol / Gas Partition Coeff. at 37°C | 1920 ± 290 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
Blood / Gas Partition Coeff. at 37°C | 7.53 ± 0.5 | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1994;79:1049-55 |
Arterial / Inspired Partial Pressure (Pa/PI) | 0.52 ± 0.04 | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1994;79:1049-55 |
Vapour Pressure at 20°C (atm) | 0.0189 | Liu J, Laster MJ, Taheri S, et al. Anesth Analg 1993;77:12-8 |
Calculated Molecular Properties | ||
van der Waals Volume | 148 Å3 | |
van der Waals Surface Area | 229 Å2 | |
Solvent Accessible Volume | 543 Å3 | (based on a 1.4Å probe) |
Solvent Accessible Surface Area | 379 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
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Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014