 This anaesthetic has more than one structural configuration. An example low energy conformer is shown. Surface View:
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Surface view shows the electrostatic potential of the conformer mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
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| In Vivo Activity Data | ||
| Immobility: MAC Rat (atm) | 0.000498 ± 0.000041 (n=8) | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
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| Physical Properties | ||
| Saline / Gas Partition Coeff. at 37°C | 23.1 ± 0.7 (n=4) | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
| Olive Oil / Gas Partition Coeff. at 37°C | 834 ± 55 (n=4) | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
| Octanol / Gas Partition Coeff. at 37°C | 7430 ± 260 (n=4) | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
| Vapour Pressure at 20°C (atm) | 0.015 | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
| Calculated Molecular Properties | ||
| van der Waals Volume | 139 Å3 | |
| van der Waals Surface Area | 188 Å2 | |
| Solvent Accessible Volume | 479 Å3 | (based on a 1.4Å probe) |
| Solvent Accessible Surface Area | 323 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
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Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014