![]() This anaesthetic has more than one structural configuration. An example low energy conformer is shown. Surface View:
On Off
Surface view shows the electrostatic potential of the conformer mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
|
|
In Vivo Activity Data | ||
Immobility: MAC Rat (atm) | 0.000498 ± 0.000041 (n=8) | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
---|---|---|
Physical Properties | ||
Saline / Gas Partition Coeff. at 37°C | 23.1 ± 0.7 (n=4) | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
Olive Oil / Gas Partition Coeff. at 37°C | 834 ± 55 (n=4) | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
Octanol / Gas Partition Coeff. at 37°C | 7430 ± 260 (n=4) | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
Vapour Pressure at 20°C (atm) | 0.015 | Eger EI II, Ionescu P, Laster MJ, et al. Anesth Analg 1999;88:867-76 |
Calculated Molecular Properties | ||
van der Waals Volume | 139 Å3 | |
van der Waals Surface Area | 188 Å2 | |
Solvent Accessible Volume | 479 Å3 | (based on a 1.4Å probe) |
Solvent Accessible Surface Area | 323 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
Use of this web site assumes acceptance of our
Copyright & Licence conditions.
Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014