![]() This anaesthetic has more than one structural configuration. An example low energy conformer is shown. Surface View:
On Off
Surface view shows the electrostatic potential of the conformer mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
|
|
In Vivo Activity Data | ||
Immobility: MAC Dog (atm) | 0.00035 ± 0.00008 (n=4) | Tanifuji Y, Eger EI II, Terrell RC. Anesth Analg 1977;56:387-90 |
---|---|---|
Physical Properties | ||
Olive Oil / Gas Partition Coeff. at 37°C | 7230 ± 50 | Tanifuji Y, Eger EI II, Terrell RC. Anesth Analg 1977;56:387-90 |
Blood / Gas Partition Coeff. at 37°C | 68.1 ± 1.5 | Tanifuji Y, Eger EI II, Terrell RC. Anesth Analg 1977;56:387-90 |
Water / Gas Partition Coeff. at 37°C | 5.4 ± 0.3 | Tanifuji Y, Eger EI II, Terrell RC. Anesth Analg 1977;56:387-90 |
Calculated Molecular Properties | ||
van der Waals Volume | 117 Å3 | |
van der Waals Surface Area | 157 Å2 | |
Solvent Accessible Volume | 437 Å3 | (based on a 1.4Å probe) |
Solvent Accessible Surface Area | 297 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
Use of this web site assumes acceptance of our
Copyright & Licence conditions.
Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014