 This anaesthetic has more than one structural configuration. An example low energy conformer is shown. Surface View:
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Surface view shows the electrostatic potential of the conformer mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
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| In Vivo Activity Data | ||
| Immobility: MAC Rat (atm) | 0.032 | Zhang Y, Eger EI II, Dutton RC & Sonner JM. Anesth Analg 2000;91:462-45 |
|---|---|---|
| Immobility: MAC Dog (atm) | 0.0304 ± 0.0053 (n=10) | Eger EI II, Brandstater B, Saidman LJ, et al. Anesthesiology 1965;26:771-7 |
| Immobility: MAC Human (atm) | 0.0192 | Saidman LJ, Eger EI II, Munson ES, et al. Anesthesiology 1967; 28:994-1002 |
| Physical Properties | ||
| Olive Oil / Gas Partition Coeff. at 37°C | 65 | Eger EI II, Brandstater B, Saidman LJ, et al. Anesthesiology 1965;26:771-7 |
| Blood / Gas Partition Coeff. at 37°C | 12 | Steward A, Allott PR, Cowles AL & Mapleson WW. Br J Anaesth 1973;45:282-93 |
| Water / Gas Partition Coeff. at 37°C | 13 | Steward A, Allott PR, Cowles AL & Mapleson WW. Br J Anaesth 1973;45:282-93 |
| Calculated Molecular Properties | ||
| van der Waals Volume | 87 Å3 | |
| van der Waals Surface Area | 137 Å2 | |
| Solvent Accessible Volume | 359 Å3 | (based on a 1.4Å probe) |
| Solvent Accessible Surface Area | 273 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
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Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014