 This anaesthetic has a single low-energy conformer. Surface View:
On Off
Surface view shows the electrostatic potential of the structure mapped onto
the solvent excluded surface, based on a probe of radius 1.4Å.
Regions of negative potential are shown in red, positive in blue.
|
|
| In Vivo Activity Data | ||
| Immobility: MAC Rat [Pa/PI Corrected] (atm) | 9.8 (n=5) | Eger EI II and Laster MJ. Anesth Analg 2001;92:1477-82 |
|---|---|---|
| Immobility: MAC Rat (atm) | 9.9 ± 1.29 (n=5) | Eger EI II and Laster MJ. Anesth Analg 2001;92:1477-82 |
| Physical Properties | ||
| Saline / Gas Partition Coeff. at 37°C | 0.0244 ± 0.0001 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
| Olive Oil / Gas Partition Coeff. at 37°C | 0.302 ± 0.004 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
| Octanol / Gas Partition Coeff. at 37°C | 0.374 ± 0.003 (n=4) | Taheri S, Laster MJ, Liu J, et al. Anesth Analg 1993;77:7-11 |
| Calculated Molecular Properties | ||
| van der Waals Volume | 26 Å3 | |
| van der Waals Surface Area | 49 Å2 | |
| Solvent Accessible Volume | 158 Å3 | (based on a 1.4Å probe) |
| Solvent Accessible Surface Area | 144 Å2 | (based on a 1.4Å probe) |
All values are mean ± SD, except
data labelled with † which are mean ± SEM.
Use of this web site assumes acceptance of our
Copyright & Licence conditions.
Database Version: 1.09.9 Last Updated: 21st February 2014
Database Version: 1.09.9 Last Updated: 21st February 2014